Jessy Mendiola

In the succeeding years, she played supporting roles in a series of television shows including Natutulog Ba Ang Diyos? (2007), Dyosa (2008), and Kung Tayo’y Magkakalayo (2010) among others. She eventually became a household name for leading several hit series like Sabel (2010), Budoy (2011), Paraiso (2012) and Maria Mercedes (2013). She also had a slew of film stints, the most notable being The Reunion (2012), Call Center Girl (2013), The Trial (2014) and The Girl in the Orange Dress (2018). Mendiola's repertoire earned her several recognitions including the 'German Moreno Youth Achievement Award' at the 2012 FAMAS Awards. She was the first Filipino recipient of the 'Best Asia Pacific Star' at the 5th Asia Pacific Actors Network (APAN) Star Awards in South Korea. She was also included for three consecutive years (2017–19) in TC Candler's list of the “Most Beautiful Faces in the World”. FHM Philippines hailed her as the "Sexiest Woman of 2016".

Jessica Mendiola Tawile was born in Dubai, where her father once worked. She is the second of three daughters born to Filipino mother Judith Mendiola and Lebanese father Roger Tawile. She was three years old when her mother Judith moved to the Philippines after her father's infidelity, bringing along her and her elder sister, Pamela. Jessy's younger sister Megan was born in Mexico, where her parents reconciled, but eventually separated again for unknown reasons. She remains in contact with her father, who works overseas as a marine anthropologist. She studied mass communication at Far Eastern University.

Jessy Mendiola was one of the 18 new talents launched by ABS-CBN under Star Magic Batch 15. She, along with Megan Young, Alfonso Martinez, Carlo Guevarra and her Star Magic batchmates, joined the cast of Star Magic Presents: Abt Ur Luv, when it was revamped to Abt Ur Luv Ur Lyf 2 in 2007. She also had a minor role in Sineserye Presents: Natutulog Ba ang Diyos?. In 2008, she was cast as Chappy Girl in the TV series Volta, which was adapted from the Star Cinema film of the same name. In 2010, she had a guest appearance in George and Cecil, playing the love interest of Dino Imperial's Jun. Mendiola revealed that she was pulled out of Habang May Buhay and was cast as Christina in the TV series Kung Tayo'y Magkakalayo instead. Mendiola was supposed to appear in Habang May Buhay and was featured in the 2008 trailer of the show which was originally titled as Humingi Ako sa Langit. The TV series, which was supposed to air in 2008, was cancelled, reshot and recast. Due to good feedback, her one-week guest appearance in Kung Tayo'y Magkakalayo was extended. She was later cast in Your Song Presents: Gimik 2010, playing the role of the reformed rebel teenager Jessy. Mendiola was supposed to appear in Kokey @ Ako, opposite Enrique Gil, but their characters were written off in favor of Melai Cantiveros and Jason Francisco. She eventually returned as a recurring character in the last few episodes of Kung Tayo'y Magkakalayo. She portrayed lead roles in Maalaala Mo Kaya: "Marriage Contract" and in Wansapanataym: "Kakambal Ko'y Manika". Her first biggest break was playing the title role in the afternoon TV show, Sabel. In 2011, when Sabel ended, Mendiola joined ASAP Rocks. She, along with Empress Schuck, Enchong Dee and Sam Concepcion, are referred to as ASAP's 'Dance Quad'. Earlier, she portrayed Isabel Valderama in Agimat: Ang Mga Alamat ni Ramon Revilla Presents: Bianong Bulag. In April, she became a guest judge for It's Showtime and appeared as Risa in the Maalaala Mo Kaya episode, "Medalyon". She also played the role of Jacqueline Marasigan in the primetime TV show, Budoy, opposite Gerald Anderson and Enrique Gil. In 2012, she starred in the film The Reunion, with Enchong Dee, Enrique Gil and Xian Lim. She also starred in the afternoon TV show Precious Hearts Romances Presents: Paraiso, with Matteo Guidicelli, Matt Evans and Jewel Mische. In 2013, Mendiola played the titular role in the Philippine remake of Maria Mercedes. In October, she flew to South Korea for a ceremonial appointment by Korea Tourism Organization as the Honorary Ambassador for Korean Tourism. In 2015, Mendiola played another lead role in the comedy drama Must Date the Playboy, alongside Kim Chiu, Xian Lim and Matt Evans. and in the romantic family drama You're My Home, alongside Dawn Zulueta, Richard Gomez and JC de Vera. In 2016, Mendiola was recognized as the No. 1 Sexiest Woman in the Philippines by the men's magazine FHM Philippines. She landed fourth place in the same list of sexiest women in the Philippines the following year. In 2024, after a five-year hiatus, she signed a contract with ABS-CBN and Star Magic. On April 25, 2026, Mendiola and Vilma Santos participated as co-contestants in the premiere episode of the revival of Kapamilya Deal or No Deal, where they won ₱125,000 for their charities.

On December 12, 2020, Mendiola became engaged to television host Luis Manzano. The two had been dating since June 2016. Mendiola and Manzano were married on February 21, 2021, in a civil wedding in Lipa, Batangas, officiated by the city mayor. In 2023, she gave birth to a daughter. On February 15, 2024, Mendiola and Manzano had their church wedding in Coron, Palawan.