Isuca

The story revolves around Shinichirō, a male student who gets a job as a housekeeper in order to pay his rent. When he unintentionally releases a strange creature into the world he learns that his female employer, named Sakuya Shimizu, is the head of the Shimizu clan that hunts these creatures. Shinichirō cooperates with her to hunt down the monsters that are running loose.

Shinichirō Asano (浅野 真一郎, Asano Shin'ichirō) Voiced by: Keisuke Koumoto Shinichirō appears to be an average high-school student but he has an unusual ability: the Eyes of Truth, which allows him to divine the True Name of a supernatural being or person with supernatural powers when he kisses them. Since the first person to speak an individual's true name gains the ability to compel said individual to do whatever he wants (within reason), he becomes a powerful ally in Sakuya's work. Unfortunately, he learns and speaks Sakuya's true name, leaving her unable to disobey him. Originally, he lived alone in his parents' apartment, since they had gone to Europe for job training (in the manga, his father is a bad stage magician and his mother his father's assistant),[ch. 1] but later was moved into Sakuya's house (ostensibly as her housekeeper) after they began working together. He becomes the wielder of the spirit sword Yashaou after learning its True Name when it possessed Sakuya and used her to nearly kill him.[ch. 4] Sakuya Shimazu (島津 朔邪, Shimazu Sakuya) Voiced by: Ibuki Kido Sakuya is the de facto or provisional 37th head of the Shimazu Family, but is in a power struggle with her younger cousin for the position. She wishes to become head of the family in order to find out what happened to her parents several years before the present. Her family is tasked with sealing monsters and spirits that cross over into this world but, unlike many in her family, does not believe that the ends justify the means and tries to keep collateral damage to a minimum. She uses a bow and arrow with several spiritual attacks in combat and, when charged-up by Shinichirō, those attacks are amplified ten-fold. At first she is reluctant to do so since it involves kissing him, but over time she comes to have feelings for him. Although she maintains a haughty attitude, her facade hides a young lady who just wants to live like a normal person. When Shinichirō discovers her True Name, she becomes unable to disobey any of his orders.[ch. 7] In order to save face and avoid losing her position in the family, she forces Shinichirō to become her fiancé, if only in name. This twist is omitted from the anime, but is hinted at by Nami Shimazu, Sakuya's grandmother, when she calls Shinichrō "Mr. Husband". Her True Name is Isuca, a name she chose after a plush bird toy given to her by her father; the Isuca is supposed to bring luck and prevent illness. Her weakness is a fear of rats and roaches.[ch. 11] Suseri Shimazu (島津 須世璃, Shimazu Suseri) Voiced by: M·A·O Suseri is Sakuya's cousin who is in the running to be the next head of the Shimazu family. She specializes in spirit summoning and wind magic. In the beginning, she seems somewhat emotionless and focused on only becoming the next head. She even tries to increase her chances of becoming the next head by attempting to steal Shinichirō away from Sakuya; an attempt by Suseri to discover Sakuya's True Name by using Shinichirō's Eyes of Truth went wrong when Shinichirō spoke Sakuya's True Name first.[ch. 7] She later transfers to the same school as Sakuya not only to steal Shinichirō away but to also investigate the appearance of so many specters at the school. As time passes, she begins to develop feelings for Shinichirō. Because she is envious and secretly admires her older cousin, Suseri chooses her True Name to be Sakuya.

Tamako (タマ子) Voiced by: Kaori Sadohara A two-tailed cat-spirit with red hair and a large bosom. She can change into a giant cat form and is the first spirit whom Shinichiro meets; in the manga, she can also assume the form of a normal-sized cat. He learns her true name when she kisses him as thanks for saving her from Sakuya (in the anime, this happens after he clears her from suspicion of a lightning beast attack). Her True Name is Tama, but at her request Shinichirō gives her the name Tamako in order to disguise her True Name. Like most spirits she needs life energy to survive, though she has never attacked anyone. True to her cat-like nature, she licks Shinichirō in affection, likes to curl up in his lap and tends to eat her meals on the floor. She also has a disturbing tendency of catching prey and bringing it to him. Nadeshiko Sōma (相馬 撫子, Sōma Nadeshiko) Voiced by: Saeko Zōgō Shinichirō and Sakuya's homeroom teacher at the high school that they attend. She has a connection with the Shimazu Family, has been appointed by the Shimazu Family as the guardian of both Sakuya and Suseri [ch. 6] and helps to clean up the messes left behind Sakuya's work. She is also responsible for getting Shinichirō his job as Sakuya's housekeeper; later, she has Shinichirō moved into Sakuya's house as part of the plan to have them pose as intending to marry and moves in as well to both keep an eye on them and to investigate Shinichirō's True Name.[ch. 9] Although she helps Sakuya, Nadeshiko supports Suseri as the next head of the family, and she loves stirring the pot now and then by flirting with Shinichirō or suggesting to the other girls ways to get closer to Shinichirō in order to make life at Sakuya's mansion interesting. Nami Shimazu (島津那巳) Voiced by: Ikue Ōtani Nami is the grandmother of Sakuya and Suseri and head of the Shimazu Family. Despite her age, she maintains the image of a young girl through the use of an artificial body created by Nadeshiko and loves to play video games. She is intrigued by Shinichirō's powers as a magan and declares that the next head of the family must marry him. When her powers to control the artificial body fades, she entrusts a jewel containing great spiritual powers to Shinichirō in hopes that he can find a way to seal it. Nami had a previous encounter with the homunculus Isuca, which is the basis of Isuca's grudge against the Shimazu family. Matsuri Sōma (相馬 茉莉, Sōma Matsuri) Voiced by: Akane Kohinata Matsuri is Suseri's attendant and assistant. She also specializes in healing spells to lower collateral damage to innocent bystanders from battles with specters. Isuca (イスカ, Isuka) Voiced by: Ayumi Fujimura Isuca holds a grudge against the Shimazu family but seems to be focusing mainly on Sakuya. However, she doesn't want to kill her immediately: she first wants to torment Sakuya by killing the people closest to her until she has given in to despair and only then will she kill her. She is revealed to be a homunculus from the Asahina family, a rival family of magic users. It is not revealed why her name is the same as Sakuya's True Name, but at the end of the anime it is shown that Sakuya's father may be involved too.

The opening song theme for the anime was "Never say Never" by Afilia Saga, while the ending song theme was "Somebody to Love" by TWO-FORMULA, a duo consisted of the singers and voice actresses Saeko Zōgō and Kaori Sadohara.